PRF sexual & vaginal rejuvenation

This fast, in-office medical treatment improves vaginal health using your own blood platelets (platelet-rich fibrin or PRF) injected into the clitoris and vaginal rugae.

First we draw your blood, then spin it in a special centrifuge to separate the PRF. While your platelets are being prepared, we numb your clitoris and vaginal area to ensure the treatment is comfortable. Numbing the vagina is easy and this treatment is generally completely pain-free.

After your PRF is drawn up in to syringes, it is injected. The PRF begins to rebuild and stimulate growth cells and collagen, leading to improved sexual response, sensitivity, and lubrication, as well as reduced urinary stress incontinence and leakage. Most people see best results after 3 months (it takes time for the youthful cells to regrow) and sensitivity improves in as little as 3-7 days.

PRF is generally considered more regenerative and longer-lasting than PRP. While the O-Shot® is more widely recognized by name, the PRF shot may offer deeper healing over time—especially when tissue repair, lubrication, and cellular health are the primary goals.

At RegenCen, we use PRF because it’s backed by science and aligns with our regenerative approach to aging and wellness.

From numbing to finish, PRF Sexual and Vaginal Rejuvenation is a short, 30-minute procedure. It’s pain-free, too!

Both the O-Shot® and PRF shot use your body’s own healing power to improve vaginal health and sexual function—but the key difference lies in what’s being injected and how it works.

The O-Shot®

• Uses PRP (Platelet-Rich Plasma)—a concentration of platelets spun from your blood

• Often injected near the clitoris and G-spot to improve arousal, sensitivity, lubrication, and orgasm

• Typically includes a fast spin process that separates plasma from other blood components

• Results can include heightened sensation, stronger orgasms, and better lubrication

• Trademarked and commonly known, but PRP has a shorter release time (meaning growth factors activate quickly and then dissipate)

The PRF Shot

• Uses PRF (Platelet-Rich Fibrin)—a newer, more advanced version of PRP

• Spun more slowly and without anticoagulants, so it forms a natural fibrin matrix that releases growth factors slowly over time

• Often used at RegenCen for longer-lasting tissue regeneration and collagen support

• Can improve sensation, lubrication, and tissue health, especially in women with dryness, mild incontinence, or postpartum/perimenopausal changes

• No chemicals or additives—just your body doing the work more efficiently

Of all the aesthetic procedures, PRF Sexual and Vaginal Rejuvenation has one of the highest “worth it” ratings on the realself.com website. Every single one of our staff who’s tried it has noticed positive results including improved sensation and responsiveness in the bedroom, longer, stronger orgasms, and better bladder control.

PRF comes from your own blood, so it’s completely natural and familiar to your body, reducing or eliminating any risk of reaction.

Though we like to say anyone (yes, even staff in their 20s love the results it brings), PRF Sexual and Vaginal Rejuvenation is especially beneficial for menopausal and post-menopausal women because hormonal changes and loss of estrogen impact sexual sensitivity as we age. Those who suffer from mild-to-moderate urinary incontinence are also great candidates for this procedure that makes it easier to laugh and wear yoga pants without fear. In fact, many postpartum women request PRF Sexual and Vaginal Rejuvenation as part of a “mommy makeover” plan.